Semaglutide vs. Tirzepatide: Which One’s Right for You? A GLP-1 Comparison Guide.

The popularity of GLP-1 medications for weight management has surged in recent years, with many patients turning to compounded semaglutide or tirzepatide for weight loss as part of their health journey. While both medications are highly effective, they work a little differently and may be more suitable for different individuals.

This GLP-1 comparison guide breaks down how they work, compares benefits and side effects, and helps you understand which might be the better fit for your goals. We know the clinical jargon can get overwhelming, for ease, we've broken these concepts down in both clinical and simplified terms.

What Are GLP-1 Medications?

Clinical Explanation

GLP-1 receptor agonists mimic the hormone GLP-1, which:

• Promotes insulin release after meals.

• Slows stomach emptying.

• Signals fullness to the brain.

Tirzepatide goes further, acting on both GLP-1 and GIP receptors for potentially greater weight loss.

Simplified Terms

GLP-1 medications mimic your body’s natural signals to steady blood sugar and curb appetite. Tirzepatide doubles up on these signals, often leading to stronger results.

Compounded Semaglutide

Clinical Explanation

• FDA-approved brands: Ozempic® (diabetes), Wegovy® (weight loss).

• Compounded versions available for customized dosing or during shortages.

• Average weight loss: 10–15% of body weight.

• Common side effects: nausea, constipation, diarrhea.

Simplified Terms

Semaglutide is proven and reliable. If brand versions aren’t available, compounded semaglutide is a safe, customized option. Most patients lose 10–15% of their weight, with mild stomach issues at first.

Tirzepatide for Weight Loss

Clinical Explanation

• FDA-approved as Mounjaro® (diabetes), pending weight loss approval.

• Average weight loss: 15–20% of body weight.

• Side effects: nausea, diarrhea, reduced appetite.

Simplified Terms

Tirzepatide works on two hormones, which often means more weight loss (15–20%). Some people find the side effects stronger at first.

GLP-1 Comparison at a Glance

Which One’s Right for You?

Clinical Explanation

Choice depends on medical history, treatment goals, insurance coverage, and tolerance.

Simplified Terms

• Semaglutide = proven & steady.

• Tirzepatide = newer & often stronger.

However, your provider can guide you toward the best fit for your body and goals—consult with them!

Bottom Line

Both compounded semaglutide and tirzepatide for weight loss are powerful tools. Semaglutide is established and widely available, while tirzepatide may deliver even greater results.

The right option comes down to your body, your goals, and your provider’s guidance.